The relation between cognition and motor dysfunction in drug‐naive newly diagnosed patients with Parkinson's disease
Identifieur interne : 000119 ( Main/Exploration ); précédent : 000118; suivant : 000120The relation between cognition and motor dysfunction in drug‐naive newly diagnosed patients with Parkinson's disease
Auteurs : Magdalena Eriksson Domellöf [Suède] ; Eva Elgh [Suède] ; Lars Forsgren [Suède]Source :
- Movement Disorders [ 0885-3185 ] ; 2011-10.
English descriptors
Abstract
Recent studies have reported cognitive decline to be common in the early phase of Parkinson's disease. Imaging data connect working memory and executive functioning to the dopamine system. It has also been suggested that bradykinesia is the clinical manifestation most closely related to the nigrostriatal lesion. Exploring the relationship between motor dysfunction and cognition can help us find shared or overlapping systems serving different functions. This relationship has been sparsely investigated in population‐based studies of untreated Parkinson's disease. The aim of the present study was to investigate the association between motor signs and cognitive performance in the early stages of Parkinson's disease before the intake of dopaminergic medication. Patients were identified in a population‐based study of incident cases with idiopathic parkinsonism. Patients with the postural instability and gait disturbances phenotype were compared with patients with the tremor‐dominant phenotype on demographics and cognitive measures. Associations between cognitive and motor scores were investigated, with age, education, and sex controlled for. Bradykinesia was associated with working memory and mental flexibility, whereas axial signs were associated with episodic memory and visuospatial functioning. No significant differences in the neuropsychological variables were found between the postural instability and gait disturbances phenotype and the tremor phenotype. Our results indicate a shared system for slow movement and inflexible thinking that may be controlled by a dopaminergic network different from dopaminergic networks involved in tremor and/or rigidity. The association between axial signs and memory and visuospatial function may point to overlapping systems or pathologies related to these abilities. © 2011 Movement Disorder Society
Url:
DOI: 10.1002/mds.23814
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">The relation between cognition and motor dysfunction in drug‐naive newly diagnosed patients with Parkinson's disease</title><author><name sortKey="Domellof, Magdalena Eriksson" sort="Domellof, Magdalena Eriksson" uniqKey="Domellof M" first="Magdalena Eriksson" last="Domellöf">Magdalena Eriksson Domellöf</name></author><author><name sortKey="Elgh, Eva" sort="Elgh, Eva" uniqKey="Elgh E" first="Eva" last="Elgh">Eva Elgh</name></author><author><name sortKey="Forsgren, Lars" sort="Forsgren, Lars" uniqKey="Forsgren L" first="Lars" last="Forsgren">Lars Forsgren</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:774A8B62AAECE9DC80F22568F3B0126F87EA7CC9</idno><date when="2011" year="2011">2011</date><idno type="doi">10.1002/mds.23814</idno><idno type="url">https://api.istex.fr/document/774A8B62AAECE9DC80F22568F3B0126F87EA7CC9/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">000486</idno><idno type="wicri:Area/Main/Curation">000421</idno><idno type="wicri:Area/Main/Exploration">000119</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">The relation between cognition and motor dysfunction in drug‐naive newly diagnosed patients with Parkinson's disease</title><author><name sortKey="Domellof, Magdalena Eriksson" sort="Domellof, Magdalena Eriksson" uniqKey="Domellof M" first="Magdalena Eriksson" last="Domellöf">Magdalena Eriksson Domellöf</name><affiliation wicri:level="1"><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Pharmacology and Clinical Neuroscience, Umeå University, Umeå</wicri:regionArea><wicri:noRegion>Umeå</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Community Medicine and Rehabilitation, Geriatric Medicine, Umeå University, Umeå</wicri:regionArea><wicri:noRegion>Umeå</wicri:noRegion></affiliation></author><author><name sortKey="Elgh, Eva" sort="Elgh, Eva" uniqKey="Elgh E" first="Eva" last="Elgh">Eva Elgh</name><affiliation wicri:level="1"><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Community Medicine and Rehabilitation, Geriatric Medicine, Umeå University, Umeå</wicri:regionArea><wicri:noRegion>Umeå</wicri:noRegion></affiliation></author><author><name sortKey="Forsgren, Lars" sort="Forsgren, Lars" uniqKey="Forsgren L" first="Lars" last="Forsgren">Lars Forsgren</name><affiliation wicri:level="1"><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Pharmacology and Clinical Neuroscience, Umeå University, Umeå</wicri:regionArea><wicri:noRegion>Umeå</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2011-10">2011-10</date><biblScope unit="volume">26</biblScope><biblScope unit="issue">12</biblScope><biblScope unit="page" from="2183">2183</biblScope><biblScope unit="page" to="2189">2189</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">774A8B62AAECE9DC80F22568F3B0126F87EA7CC9</idno><idno type="DOI">10.1002/mds.23814</idno><idno type="ArticleID">MDS23814</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Parkinson's disease</term><term>cognition</term><term>newly diagnosed</term><term>population based</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Recent studies have reported cognitive decline to be common in the early phase of Parkinson's disease. Imaging data connect working memory and executive functioning to the dopamine system. It has also been suggested that bradykinesia is the clinical manifestation most closely related to the nigrostriatal lesion. Exploring the relationship between motor dysfunction and cognition can help us find shared or overlapping systems serving different functions. This relationship has been sparsely investigated in population‐based studies of untreated Parkinson's disease. The aim of the present study was to investigate the association between motor signs and cognitive performance in the early stages of Parkinson's disease before the intake of dopaminergic medication. Patients were identified in a population‐based study of incident cases with idiopathic parkinsonism. Patients with the postural instability and gait disturbances phenotype were compared with patients with the tremor‐dominant phenotype on demographics and cognitive measures. Associations between cognitive and motor scores were investigated, with age, education, and sex controlled for. Bradykinesia was associated with working memory and mental flexibility, whereas axial signs were associated with episodic memory and visuospatial functioning. No significant differences in the neuropsychological variables were found between the postural instability and gait disturbances phenotype and the tremor phenotype. Our results indicate a shared system for slow movement and inflexible thinking that may be controlled by a dopaminergic network different from dopaminergic networks involved in tremor and/or rigidity. The association between axial signs and memory and visuospatial function may point to overlapping systems or pathologies related to these abilities. © 2011 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Suède</li></country></list><tree><country name="Suède"><noRegion><name sortKey="Domellof, Magdalena Eriksson" sort="Domellof, Magdalena Eriksson" uniqKey="Domellof M" first="Magdalena Eriksson" last="Domellöf">Magdalena Eriksson Domellöf</name></noRegion><name sortKey="Domellof, Magdalena Eriksson" sort="Domellof, Magdalena Eriksson" uniqKey="Domellof M" first="Magdalena Eriksson" last="Domellöf">Magdalena Eriksson Domellöf</name><name sortKey="Elgh, Eva" sort="Elgh, Eva" uniqKey="Elgh E" first="Eva" last="Elgh">Eva Elgh</name><name sortKey="Forsgren, Lars" sort="Forsgren, Lars" uniqKey="Forsgren L" first="Lars" last="Forsgren">Lars Forsgren</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000119 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000119 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= ParkinsonV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:774A8B62AAECE9DC80F22568F3B0126F87EA7CC9
|texte= The relation between cognition and motor dysfunction in drug‐naive newly diagnosed patients with Parkinson's disease
}}
| This area was generated with Dilib version V0.6.23. |  |